Introduction and objectives: Water quality and heath of rivers are the most important factors to achieve sustainable development. Doogh River is one of the main tributaries of Gorganroud river in the east of Golestan province, which has an important role in supplying drinking water to Gonbad Kavous. Furthermore, it is one of the water supply sources of Golestan dam with agriculture use. Therefore, the study of hydrochemical and water quality of this river for different uses (e. g., drinking, agricultural, and industrial), is of great importance Materials and Methods: In this study, Stiff, Piper and Gibbs diagrams were used to investigate Doogh River hydrochemistry. Wilcox, sodium soluble percentage, magnesium ratio, and permeability index was evaluated to classify water for irrigation purpose. To investigate Doogh River water for drinking purpose, NSFWQI index, Schoeller diagram, and water quality standards were used. Eventually, water quality for industry was assessed using Langelier Saturation Index, Ryznar Stability Index, and corrosivity ratio. Findings and discussion: Hydrochemical results showed Ca-Mg-HCO3 is dominant hydrochemical facies and rock-water interaction is the main controlling factor in river water chemistry. According to NSFWQI index and Schoeller diagram, river water was in the acceptable class for drinking purpose. While, based on water quality standards, turbidity and fecal coliforms values were higher than drinking limit and needs to be purified. Based on the results of sodium percentage, magnesium ratio, and permeability index, water quality is well evaluated for agriculture purpose. Industrial indices indicate that the relatively corrosive property. According to the results of this study, Doogh River water requires two physical and microbial purifications for drinking purpose. Water quality for irrigation purpose is well evaluated and there is no need for soil regeneration after use. Although Doogh River water is relatively corrosive, but it is save to use all metallic equipment to transfer and extract water.